Raining Blood 
                                                                

The song was featured in the 127th South Park episode Die Hippie, Die aired on March 16, 2005. The plot centers on the town of South Park, which has been overrun by hippies. Eric Cartman states "Hippies can't stand death metal" and proceeds to hijack a hippie concert by drilling through the mass of hippies with a giant armoured drilling vehicle. He makes it onto the main stage to change the audio to "Raining Blood", in turn upsetting the hippies and making them flee. Slayer guitarist Kerry King found the episode humorous and expressed his interest in the show, mentioning it in an interview, saying "It was good to see the song being put to good use, if we can horrify some hippies we've done our job.Raining Blood" was also included in the Grand Theft Auto: Vice City in-game radio station V-Rock.^["Raining Blood" is a playable song in the Activision music video game Guitar Hero III: Legends of Rock, where it is renowned for being one of the hardest songs in the Career Mode setlist. It is also featured in the skateboarding game Skate. "Raining Blood" has also become a staple at Pittsburgh Penguins games at Mellon Arena, as it was most recently played January 21st, 2007 against the Washington Capitals.

In 2001 the song was covered by Tori Amos on her album Strange Little Girls. King states the cover was odd; "It took me a minute and a half to find a spot in the song where I knew where she was. It's so weird. If she had never told us, we would have never known. You could have played it for us and we'd have been like, 'What's that?' Like a minute and a half through I heard a line and was like, 'I know where she's at!'"In response, Slayer sent some T-shirts back to Amos, which she said was appreciated. ^[5] The song was also covered by Malevolent Creation, Chimaira, Vader, Diecast, and Erik Hinds, who covered the entire album on a H'arpeggione.

The guitar riffs from "Raining Blood" and "Mandatory Suicide" were sampled by rapper Lil Jon in the song "Stop Fuckin Wit' Me" from the album 2004 Crunk Juice. It was Rick Rubin's only collaboration with Lil Jon on the record, Jon wanted to attempt to create a black version of Suicidal Tendencies "Institutionalized".